Has there ever been a 10–1 in the Liga MX?

Yes, 2 times.

The first time: March 31, 1946, España beat Monterrey (España 10–1 Monterrey).

The last time: September 21, 1947, León beat Atlante (Atlante 1–10 León), 79 years ago.

Home wins: 1. Away wins: 1.

Nearby scores

1. 11–0 Never
2. 11–1 Never
3. 11–2 Never
4. 10–0 Never
5. 10–1 2 times
6. 10–2 1 time
7. 9–0 2 times
8. 9–1 1 time
9. 9–2 6 times

All games

1. September 21, 1947 Atlante 1–10 León
2. March 31, 1946 España 10–1 Monterrey