Has there ever been a 7–3 in the Serie A?

Yes, 7 times.

The first time: February 8, 1931, Brescia Calcio beat Alessandria (Brescia Calcio 7–3 Alessandria).

The last time: May 7, 2017, Lazio beat Sampdoria (Lazio 7–3 Sampdoria), 9 years ago.

Home wins: 5. Away wins: 2.

Nearby scores

1. 8–2 6 times
2. 8–3 Never
3. 8–4 Never
4. 7–2 15 times
5. 7–3 7 times
6. 7–4 1 time
7. 6–2 62 times
8. 6–3 25 times
9. 6–4 4 times

All games

1. May 7, 2017 Lazio 7–3 Sampdoria
2. October 4, 1992 ACF Fiorentina 3–7 AC Milan
3. January 18, 1953 Udinese Calcio 7–3 Pro Patria
4. October 16, 1949 Venezia 3–7 Sampdoria
5. January 19, 1947 Juventus FC 7–3 Venezia
6. April 3, 1932 Juventus FC 7–3 AS Bari
7. February 8, 1931 Brescia Calcio 7–3 Alessandria