Has there ever been a 10–1 in the La Liga?

Yes, 5 times.

The first time: September 11, 1949, FC Barcelona beat Gimnàstic de Tarragona (FC Barcelona 10–1 Gimnàstic de Tarragona).

The last time: January 4, 1959, Real Madrid beat UD Las Palmas (Real Madrid 10–1 UD Las Palmas), 67 years ago.

Home wins: 5. Away wins: 0.

Nearby scores

1. 11–0 Never
2. 11–1 1 time
3. 11–2 1 time
4. 10–0 3 times
5. 10–1 5 times
6. 10–2 1 time
7. 9–0 12 times
8. 9–1 5 times
9. 9–2 2 times

All games

1. January 4, 1959 Real Madrid 10–1 UD Las Palmas
2. September 23, 1951 Athletic Bilbao 10–1 Real Zaragoza
3. November 5, 1950 Deportivo La Coruña 10–1 UE Lleida
4. October 23, 1949 Celta de Vigo 10–1 Gimnàstic de Tarragona
5. September 11, 1949 FC Barcelona 10–1 Gimnàstic de Tarragona