Has there ever been a 12–0 in the Premier League?

Yes, 2 times.

The first time: April 4, 1892, West Bromwich Albion beat Darwen (West Bromwich Albion 12–0 Darwen).

The last time: April 21, 1909, Nottingham Forest beat Leicester City (Nottingham Forest 12–0 Leicester City), 117 years ago.

Home wins: 2. Away wins: 0.

Nearby scores

1. 13–0 Never
2. 13–1 Never
3. 12–0 2 times
4. 12–1 Never
5. 11–0 Never
6. 11–1 Never

All games

1. April 21, 1909 Nottingham Forest 12–0 Leicester City
2. April 4, 1892 West Bromwich Albion 12–0 Darwen