Has there ever been a 10–0 in the Premier League?

Yes, 5 times.

The first time: September 14, 1889, Preston North End beat Stoke City (Preston North End 10–0 Stoke City).

The last time: January 19, 1929, Sheffield United beat Burnley (Sheffield United 10–0 Burnley), 97 years ago.

Home wins: 5. Away wins: 0.

Nearby scores

1. 11–0 Never
2. 11–1 Never
3. 10–0 5 times
4. 10–1 4 times
5. 9–0 12 times
6. 9–1 11 times

All games

1. January 19, 1929 Sheffield United 10–0 Burnley
2. October 20, 1928 Leicester City 10–0 Portsmouth
3. August 29, 1925 Aston Villa 10–0 Burnley
4. October 5, 1912 Aston Villa 10–0 Sheffield Wednesday
5. September 14, 1889 Preston North End 10–0 Stoke City