Has there ever been a 10–1 in the Premier League?

Yes, 4 times.

The first time: October 15, 1892, Manchester United beat Wolverhampton Wanderers (Manchester United 10–1 Wolverhampton Wanderers).

The last time: December 26, 1963, Fulham beat Ipswich Town (Fulham 10–1 Ipswich Town), 62 years ago.

Home wins: 4. Away wins: 0.

Nearby scores

1. 11–0 Never
2. 11–1 Never
3. 11–2 1 time
4. 10–0 5 times
5. 10–1 4 times
6. 10–2 Never
7. 9–0 12 times
8. 9–1 11 times
9. 9–2 7 times

All games

1. December 26, 1963 Fulham 10–1 Ipswich Town
2. April 15, 1938 Wolverhampton Wanderers 10–1 Leicester City
3. December 13, 1930 Huddersfield Town 10–1 Blackpool
4. October 15, 1892 Manchester United 10–1 Wolverhampton Wanderers