Has there ever been a 7–3 in the Premier League?

Yes, 24 times.

The first time: March 9, 1889, Bolton Wanderers beat Notts County (Bolton Wanderers 7–3 Notts County).

The last time: December 29, 2012, Arsenal beat Newcastle United (Arsenal 7–3 Newcastle United), 13 years ago.

Home wins: 18. Away wins: 6.

Nearby scores

1. 8–2 16 times
2. 8–3 6 times
3. 8–4 2 times
4. 7–2 48 times
5. 7–3 24 times
6. 7–4 12 times
7. 6–2 184 times
8. 6–3 70 times
9. 6–4 16 times

All games

1. December 29, 2012 Arsenal 7–3 Newcastle United
2. January 2, 1960 Newcastle United 7–3 Manchester United
3. November 9, 1957 Burnley 7–3 Leicester City
4. February 16, 1957 Wolverhampton Wanderers 7–3 Charlton Athletic
5. October 6, 1956 Arsenal 7–3 Manchester City
6. September 3, 1955 Blackpool 7–3 Sunderland
7. September 16, 1953 Newcastle United 3–7 West Bromwich Albion
8. November 8, 1952 Wolverhampton Wanderers 7–3 Manchester City
9. December 9, 1950 Middlesbrough 7–3 Charlton Athletic
10. April 28, 1934 Leicester City 3–7 Birmingham City
11. December 26, 1933 Everton 3–7 Newcastle United
12. September 20, 1930 Blackpool 3–7 Leeds United
13. March 5, 1927 Newcastle United 7–3 Everton
14. September 11, 1926 Bury 7–3 West Bromwich Albion
15. August 30, 1926 Tottenham Hotspur 7–3 Sheffield Wednesday
16. October 10, 1925 Sunderland 7–3 Everton
17. March 4, 1912 Sheffield United 7–3 Bradford City
18. April 20, 1910 Liverpool 7–3 Nottingham Forest
19. December 25, 1909 Middlesbrough 3–7 Bradford City
20. December 19, 1903 Nottingham Forest 3–7 Aston Villa
21. September 7, 1895 Aston Villa 7–3 Birmingham City
22. September 9, 1893 Derby County 7–3 Everton
23. December 27, 1890 Everton 7–3 Burnley
24. March 9, 1889 Bolton Wanderers 7–3 Notts County